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Cleanance Comedomed, an innovation from the Eau Thermale Avène laboratories, has been clinically proven effective after seven days*, combating pimples at the root and preventing their reappearance.

To treat and prevent acne, proper hygiene is essential to keep the pores clean. To treat acne, it is necessary to use a specific treatment product. Regulating the skin's sebum and moisturising the skin are essential steps to keep the treatment working and the skin stable. Protecting the skin from the sun will prevent marks and worsening of acne.
Cleanance Comedomed, an innovation from the Eau Thermale Avène laboratories, has clinically proven efficacy after seven days*, combating pimples at their root and preventing their reappearance. Expert care for oily and blemish-prone skin, Cleanance Comedomed is formulated with Comedoclastin™, a plant extract derived from milk thistle seeds. This active ingredient with patented properties** acts directly on microcomedones, reduces existing pimples and blackheads, limits the appearance of new blemishes and regulates sebum hyperproduction. Cleanance Comedomed is suitable for adults and adolescents from the age of 12, is applied twice a day, morning and evening, and offers a clinically proven*** anti-redness action. Non-comedogenic and high-tolerance* for blemish-prone skin, its fast-absorbing, non-greasy texture leaves skin mattified.
*Tolerance and efficacy study under dermatological control on 51 subjects, use of Cleanance Comedomed twice a day for 56 days.
** Patent pending.
***International observational clinical study, 90% of patients with no reappearance of imperfections after 6 months, (according to the GEA protocol definition of relapse ≥3 with need for introduction of oral or local pharmacological treatment), 48 subjects, two applications per day of Cleanance Comedomed for six months.
Benefits:
- EFFECTIVE: on all types of imperfections. Tested on more than 4,000 people.
- FAST: reduces pimples in just seven days*. Limits reappearance for one year**.
- EXCELLENT TOLERANCE on all skin types, even the most sensitive. Recommended by dermatologists***.
*Clinical score, 2 times a day on the face, 51 people.
** International observational clinical study, 85% of patients with no reappearance of blemishes after 1 year (according to the GEA protocol's definition of relapse ≥3 years).(according to the GEA ≥3 protocol definition of relapse requiring the introduction of an oral or local pharmacological treatment), 54 persons, 2 applications of Cleanance Comedomed per day for 1 year.
*** IQVIA - Xponent PharmaOne - Imperfections market (83A1A) in pharmacies in France - Year 2021 - volume & value.
AVENE THERMAL SPRING WATER (AVENE AQUA). ISOPROPYL ALCOHOL. PEG-6. GLYCERIN. SILYBUM MARIANUM FRUIT EXTRACT. SILICA. POLYACRYLATE-13. POLYISOBUTENE. POLYSORBATE 20. SORBITAN ISOSTEARATE. WATER (AQUA)
Comedomed can be used alone, in combination or after a drug treatment.
Apply 1 dose of Cleanance Comedomed to the fingertips and spread over cleansed facial skin.
- Begin application on the T-zone and cheeks.
- Use circular movements to enhance penetration.
- Finish by spreading over the cheeks and lower face.
Reapply morning and evening.
Expert advice :
Our advice : adopt a short but essential routine
- 1 thorough facial cleansing or make-up removal, morning and evening.
- 1 anti-imperfection treatment, morning and evening.
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