Comboline Dogs 20-40 Kg 18 Pip Merial

COMBOLINE® SPOT-ON FOR DOGS
External anti-parasitic topical solution
Pharmaceutical form
Spot-on solution (Sol.s-o.)

Composition per pipette:
- 0.67 ml pipette: fipronil 67 mg; (S)-methoprene 60.30 mg; butylated hydroxyanisole (E 320) 0.13 mg; butylated hydroxytoluene (E 321) 0.07 mg; ethanol; polysorbate 80 (E 433); povidone; diethylene glycol monoethyl ether.
- 1,34 ml pipette: Fipronil 134 mg; (S)-methoprene 120,6 mg; butylated hydroxyanisole (E 320) 0,27 mg; butylated hydroxytoluene (E 321) 0,13 mg; ethanol; polysorbate 80 (E 433); povidone; diethylene glycol monoethyl ether.
- 2,68 ml pipette: Fipronil 268 mg; (S)-methoprene 241,2 mg; butylated hydroxyanisole (E 320) 0,54 mg; butylated hydroxytoluene (E 321) 0,27 mg; ethanol; polysorbate 80 (E 433); povidone; diethylene glycol monoethyl ether.
- 4.02 ml pipette: Fipronil 402 mg; (S)-methoprene 361.8 mg; butylated hydroxyanisole (E 320) 0.8 mg; butylated hydroxytoluene (E 321) 0.4 mg; ethanol; polysorbate 80 (E 433); povidone; diethylene glycol monoethyl ether.

Pharmacological properties
The product is an insecticidal, acaricidal solution for topical use containing an association of an adulticidal active substance, fipronil, in combination with an ovicidal and larvicidal active substance, (S)-methoprene.
Fipronil is an insecticide/acaricide belonging to the phenylpyrazole family. It acts by interacting with ligand-regulated chloride channels.
(S)-methoprene is an insect growth regulator (IGR) of the class of compounds known as juvenile hormone analogues that inhibit the development of immature stages of insects.

Interactions and incompatibilities
None known.